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Proposition 65 Safe Harbor Levels - No Significant Risk Levels for Carcinogens and Maximum Allowable Dose Levels for Chemicals Causing Reproductive Toxicity

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is the lead agency for the implementation of Proposition 65*. In that role, OEHHA has developed Proposition 65 safe harbor levels – No Significant Risk Levels (NSRLs) for carcinogens and Maximum Allowable Dose Levels (MADLs) for chemicals that cause reproductive toxicity. The NSRL is the daily intake level for a chemical calculated to result in one excess case of cancer in an exposed population of 100,000, assuming lifetime exposure to the chemical at the level in question. The MADL is the level at which a chemical listed for reproductive toxicity would have no observable effect assuming exposure at 1,000 times that level. NSRLs and MADLs assist interested parties in determining whether warnings are required for exposures to listed chemicals, and whether discharges of listed chemicals to sources of drinking water are prohibited. NSRLs and MADLs are promulgated as regulations in Title 27, California Code of Regulations, sections 25705, 25709, and 25805. Includes data on acrylamide.

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